OS Essentials Hybrid 50:1

Genetic:

Hybrid

Excipient:

Medium-chain triglycerides (MCT)

Potency:

50mg/mL THC 10
<1 mg/mL CBD

Route of administration:

Oral

Onset of action:

60-180 minutes

Duration of action:

6 and 8 hours

Main Terpenes:

Alpha-Bisabolol, Beta Eudesmol, Phytol, Nerolidol, Beta-Caryophyllene

Indication

– Appetite Stimulating
– CINV
– Chronic Pain
– Spasticity
– Palliative Care
– Sleep Disorders
– Other Indications as Clinically Justified

References

1. Razmovski-Naumovski V, Luckett T, Amgarth-Duff I, Agar MR. Efficacy of medicinal cannabis for appetite-related symptoms in people with cancer: A systematic review. Palliat Med. 2022;36(6):912-927. doi: 10.1177/02692163221083437 .
2. Therapeutic Goods Administration (TGA). Guidance for the use of medicinal cannabis in the prevention and management nausea and vomiting in Australia. January 25, 2024. https://www.tga.gov.au/medicinal-cannabis-guidance-documents
3. Razmovski-Naumovski V, Luckett T, Amgarth-Duff I, Agar MR. Efficacy of medicinal cannabis for appetite-related symptoms in people with cancer: A systematic review. Palliat Med. 2022;36(6):912-927. doi: 10.1177/02692163221083437 .
4.Therapeutic Goods Administration (TGA). “Guidance for the use of medicinal cannabis in the treatment of chronic non-cancer pain in Australia”. January 25, 2024. https://www.tga.gov.au/medicinal-cannabis-guidance-documents.
5.Therapeutic Goods Administration (TGA). Guidance for the use of medicinal cannabis in the treatment of chronic non-cancer pain in Australia. January 25, 2024. https://www.tga.gov.au/medicinal-cannabis-guidance-documents.
6. Therapeutic Goods Administration (TGA). Guidance for the use of medicinal cannabis in the treatment of multiple sclerosis in Australia. January 25, 2024. https://www.tga.gov.au/medicinal-cannabis-guidance-documents.
7. Therapeutic Goods Administration (TGA). Guidance for the use of medicinal cannabis in the treatment of palliative care patients in Australia. January 25, 2024. https://www.tga.gov.au/medicinal-cannabis-guidance-documents.
8. Suraev A, Mills L, Abelev SV, Arkell TR, Lintzeris N,McGregor IS. Medical Cannabis Use Patterns for Sleep Disorders in Australia: Results of the Cross-Sectional CAMS-20 Survey. Nat Sci Sleep. 2023;15:245-255. doi: 10.2147/NSS.S390583.

Titration and dosing

THESE TITRATION MODELS SERVE AS AN EXAMPLE AND MUST BE ADAPTED TO EACH PATIENT

Days	Morning dose (mL of oral solution)	Evening dose (mL of oral solution)	Total daily dose (mL of oral solution)	THC total daily dose (mg)
1–2*	0	0.1	0.1	2.5
3–4	0	0.1	0.1	2.5
5–6	0.1	0.1	0.2	5
7–8	0.1	0.2	0.3	7.5
9–10	0.2	0.2	0.4	10
11–12	0.2	0.3	0.5	12.5

Titration scheme and practical dosing recommendations:

The patient should take the minimum dose that provides effective symptom relief with tolerable side effects.
The titration should be conservative, done with increments of 2.5 mg THC every 2 days (or with increments of 1.25 mg THC for fragile patients).

The dosage protocol can be adjusted according to the patient’s profile. Increase dose as necessary and as tolerated, up to 15 mg of THC. Daily THC doses exceeding 20–30 mg may elevate the risk of adverse events or lead to the development of tolerance without improving efficacy.1 Maximum recommended daily THC dose: 40 mg.

*Ideally, the administration should start with an evening dose to limit adverse events and encourage the development of tolerance.

References

1. MacCallum CA, Russo EB. Practical considerations in medical cannabis administration and dosing. EwoRean Journal of Internal Medicine. 2018; 49: 12-19.

Terpenes and Minor Cannabinoids profile

* Relative content of minor cannabinoids is calculated based on the total of minor cannabinoids.
** These percentages are relative and have been determined using high-performance liquid chromatography as part of our quality control process. Please note that they may vary from batch to batch.

Consumer Medicine Information